https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43429 P ≤ .05). Only GPC showed positive correlation with all fatigue domains (r = .537, P ≤ .05). On the other hand, Glx-upper, NAA-2, GSH+Hca, and fucose-3 showed negative correlations with all fatigue domains (r = –.345 to –.580, P ≤ .05). While tyrosine showed positive correlation with MFIS (r = .499, P ≤ .05), cognitive fatigue was negatively correlated with total GSH (r = –.530, P ≤ .05). No correlations were found between lesion load or brain volumes with fatigue score. CONCLUSIONS: Our results suggest that fatigue in MS is strongly correlated with an imbalance in neurometabolites but not structural brain measurements.]]> Mon 19 Sep 2022 09:29:20 AEST ]]> Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40208 Mon 01 Aug 2022 09:10:25 AEST ]]>